All season, the new ground has been springing up, eating into a corner of the crumbling White Hart Lane.
"It's not just a stadium that supporters leave behind, not mere concrete and brick".
The game kicks off at 1630 BST at White Hart Lane, live on Sky Sports 1.
Watch Tottenham vs. United to find out.
Pochettino admitted he felt disappointed after falling short behind Chelsea in the title race and says the club now needs to move forwards in their temporary Wembley home next season and then in their new stadium from 2018/19.
David De Gea comes in for Europa League specialist Sergio Romero, whilst after his impressive display against Arsenal, Axel Tuanzebe again starts, this time in place of Antonio Valencia.
Tottenham will bid an emotional farewell to White Hart Lane - their home of 118 years - against Manchester United today. They have been prepared to win the league and win big things.
The Premier League paid tribute to some of the gifted players that played at the lane with the likes of Glenn Hoddle, Bill Nicholson, Ricky Villa, Ossie Ardiles, Jürgen Klinsmann and Gareth Bale all appearing in this rousing video. When you look at our points tally compared to last season, obviously we're disappointed losing out on the title but we are growing.
Tottenham Hotspur effectively conceded the league title after their surprise 1-0 defeat at West Ham United last weekend, but they'll be determined to bounce back with a victory against Manchester United, who might be exhausted from their midweek Europa League exploits.
Manchester United have failed to score in their last two away league trips to White Hart Lane - in the Premier League era, they've only failed to score in three consecutive away games against an opponent twice - Everton (three games between August 2012 and April 2015) and Chelsea (four games between November 2003 and May 2007).
That goal took his season tally to 22, while he has now scored against 24 of the 25 Premier League rivals he has faced, barring Cardiff City. Their league position has improved in the last couple of years, with a first finish above Arsenal in twenty-two years even coming this time (St. Tottingham's Day cancelled), but the long term goal would be lifting that first piece of silverware under their Argentine boss and improving results in Europe. Their club record for fewest goals conceded in an entire league campaign is 32 in 1908-09 and 1919-20 (both in the second tier). Four of the seven games have finished 0-0.
While it was a party atmosphere for the hosts, who are seven points behind champion Chelsea, it was another miserable day for Jose Mourinho in his erratic first season in charge of United. "We so badly wanted to win this game".