Manchester United will field one of the weakest sides in their recent history in the Premier League finale against Palace with all eyes on next Wednesday's Europa League final with Ajax.
"It's surgery, one knee, another knee, a foot, big surgeries, less players and less players, very hard, but we are there and we go to the final the best we can".
Mourinho also said centre-back Eric Bailly, who is suspended for the final, would feature, as well as Paul Pogba, who has been granted compassionate leave following the death of his father last Friday.
Manchester United face Crystal Palace at Old Trafford on Sunday (May 21) for the last game of the season.
Manchester United manager Jose Mourinho during the EPL match at Southampton May 17, 2017.
Numerous first-team players will be rested ahead of the Ajax match, with captain Wayne Rooney set to be among them after playing 90 minutes at Southampton on Wednesday. "It is important to keep the good focus about the pitch and we have the possibility to finish (eighth in) the table".
Peter Bosz has reiterated that Manchester United can not use fatigue as an excuse ahead of next week's Europa League final against his Ajax side.
"We will get more money in the turnover and if you get more money in the turnover you'll get extra budget (for wages and transfers)".
"I think if a team goes to the Champions League and doesn't qualify they should go home".
"And I hope that Big Sam (Allardyce, the Palace manager) shows he is a good friend and he goes slow". Hopefully we don't have problems with these two keepers. I don't lose time [requesting a switch I don't believe they would grant].
"Smalling has a problem, a small problem that I think it is no problem for next week, but is a problem for the weekend. Sergio had a very good performance, more than very good", Mourinho said.
Palace are now 13th going into the final weekend of the season but can end up anywhere between 11th and 16th depending on how they do against United and how other results go.