But that did not stop West Indies from fighting back as Chase along with Devendra Bishoo (3) negotiated 88 deliveries between them but Mohammad Abbas (1-31) provided respite for Pakistan when he surprised the latter with a bouncer that he nicked behind to the keeper.
Departing stalwarts Younis Khan and captain Misbah ul Haq failed to make an impact in their farewell global innings but Pakistan were poised to press for a series-clinching victory over the West Indies at stumps on the fourth day at Windsor Park in Dominica on Saturday.
West Indies and Pakistan were involved in a dramatic third and final Test at Windsor Park in Dominica which the visitors won by 101 runs to clinch the series 2-1.
Pace bowler Yasir Shah took five for 92 - his 11th Test five-for - as the hosts were all out for 202 in their second innings with just six balls remaining despite a courageous, unbeaten 101 from Roston Chase.
However, on the final ball of the penultimate over of the day, Pakistan began their celebrations as Shannon Gabriel was clean bowled by Yasir for four runs.
Medium-pacer Alzarri Joseph took out the next three wickets of Sarfraz Ahmed (4), Asad Shafiq (13) and Mohammad Amir (27) in the last session but bowlers Amir and Shah had already done the damage with their bats.
With the series tied at 1-1, the hosts were set 304 and Roston Chase made an unbeaten 101 - but they were all out for 202, Yasir Shah taking 5-92.
While congratulating the Pakistan team for their history-making series victory in the West Indies, chief selector Inzamam-ul-Haq on Monday said the replacements of both Misbah-ul-Haq and Younis Khan would emerge in the future.
Here are a few highlights from his career, considering which Misbah ul Haq can rightly be called Pakistan's number one captain. I'm happy with what I've had in my career, couldn't have asked for a better finish.
"Both these batsmen have given so much to the sport and fans over their careers", Richardson said. We performed, I performed so there's nothing left that I really wanted to do. Not just Pakistan. Even in West Indies, all the guys they've been coming to me, wishing me all the best for the rest of life. It was a fine journey with him in the middle, sharing a lot of partnerships. If you do, then automatically players get behind you and start playing their roles. "In the history books, my name will come with him and he's a legend", said Misbah. "I thought that really was the key, seeing that he was there all series, so once I got through him it was a little easier for me to play the other bowlers". "You have to go winning and performing well'".