The former French Open champion will be contesting her second Wimbledon final, but for Williams it will be a ninth, 16 years after her first and Muguruza admitted that she does not believe she will be able to match that longevity. The second-seeded Russian pair have now won three of the Grand Slam events in doubles following their triumph at the French Open in 2013 and the US Open a year later.
The women's doubles final was another disappointment though - Russians Ekaterina Makarova and Elena Vesnina cruising to a 6-0 6-0 victory over the pairing of Taiwan's Hao-Ching Chan and Romanian Monica Niculescu in a championship match that lasted 54 minutes.
Watching her charge from the customary Centre Court territory of the players' box, in this match as in others this Fortnight, she could be heard urging on Muguruza with cries of: "Grande!" - not only applause for a literal "big" shot, but more importantly an instruction to continue in that vein.
The win came to Muguruza with words from the lips of Serena Wiiliams, sister of Venus, still ringing in her ears from two years ago.
The Duke and Duchess of Cambridge are expected to be joined by the prime minister, Theresa May, and the mayor of London, Sadiq Khan.
"She's going to have more experience", said the 45-year-old. I think she played amazing. Unfortunately, this year's Wimbledon recorded the highest number of pull-outs due to injury that robbed the tournament of its glitz. I tried to build her confidence.
"It's great that two Brits are in the final, but it doesn't really make any difference". She was very open and very positive throughout the whole tournament.
"I was expecting the best Venus, because she was playing very good", Muguruza said. "Hopefully that's going to sink in".
Muguruza can say the same, of course, and she was particularly thrilled at the thought of the player she beat to earn the trophy.
Williams has always worked to the motto 'if you're hurt you don't play and if you play you're not hurt'. I feel like I have joined an incredible, historic club. There were little signs of nerves but once in the rally, she dominated, Williams netting a backhand to hand over the set 7-5. Every match, I was increasing my level.