Chan and Niculescu lost 0-6, 0-6 to the second-seeded Russian pair in a match that lasted just 54 minutes.
It was Makarova and Vesnina's second attempt at the Wimbledon doubles title.
It was a dominant women's doubles final at Wimbledon. We were sitting in the locker room, I told Katia, I was like, "Katia, we have to win Wimbledon". We won it in 2013.
The 23-year-old Taiwanese player also thanked her Taiwan fans, who she said stayed up late into the night to cheer for her.
With a light rain falling and the women's final between Venus Williams and Garbine Muguruza due to start in about an hour, the roof over the main stadium has already been closed to ensure play will begin on time. We had that close final two years ago, lost 5-7 in the third. "We need to finish it in the right way".
Wimbledon, the third Grand Slam tournament of the season, with a prize money of 31.6 million pounds ($41.3 million) will finish on Sunday.