At about 2:15 p.m. CST on Saturday, Big River RCMP were called to the crash on Revo Lake Road, just off of Highway 55.
A 75 year old woman who was a passenger in an SUV died after the accident with two others being taken to hospital with undetermined injuries.
All three are from Saskatoon.
The second collision happened 45 minutes later when a pick-up truck rolled over on Highway 47 south of Melville.
The driver, a 27-year-old man from the Lemberg area was pronounced dead at the scene.
An RCMP traffic reconstructionist and the provincial coroners office continue to investigate.