In the case of Sanchez it's safe to say most Arsenal fans wouldn't have expected to see him playing in their season opener anyway, but probably because he would've been sold after returning from worldwide action late in preseason.
Arsenal is set to receive an £80 million (about $104 million) bid from Paris Saint-Germain for Alexis Sanchez, according to reports.
And he remains one of Arsenal's most important players, capable of turning a game on its head with a single moment of inspiration.
Pressed by fellow panellist and BBC Match of the Day presenter Gary Lineker whether he genuinely did not know until the latter stage of the season whether he knew he would be staying or not, Wenger said: "No".
"Sanchez is a loss of course but we have all the other players prepared".
"(PSG) are looking for (Kylian) Mbappe, that's what I read in the papers.
"Always when I have faced opposition or unhappiness, I try to focus on what I think is important in the game, work harder and question myself, what can I improve?"
"We need to transform the quality of the preparation into points and that is, of course, a pragmatic view, but what matters is we win the game and start in a strong way, which we didn't do a year ago".
Ozil is a doubt against Leicester, however, along with Aaron Ramsey, Per Mertesacker and Shkodran Mustafi, while Laurent Koscielny is suspended.
"I think we are not open to any offers anyway".
The Premier League's longest-serving manager also touched upon his indecision regarding extending his Arsenal contract last season, suggesting it created an unease amongst his players.