Many of them condemned the violence, while others obliquely criticized the president's reluctance to initially condemn the group of protestors that included neo-Nazis, KKK members and white nationalists.
Frazier, chairman and CEO of Merck & Co.
In a statement released on Twitter, the leader of the pharmaceutical giant explained his decision, saying "America's leaders must honour our fundamental values by clearly rejecting expressions of hatred, bigotry and group supremacy, which run counter to the America ideal that all people are created equal".
The second tweet added: "Merck Pharma is a leader in higher & higher drug prices while at the same time taking jobs out of the U.S. Bring jobs back & LOWER PRICES!"
The response, and the speed in which it arrived, caught many off guard.
Frazier resigned from the manufacturing council on Monday morning after the president failed to explicitly denounce white supremacists after violent clashes over the weekend. "Johnson & Johnson has a responsibility to remain engaged, not as a way to support any specific political agenda, but as a way to represent the values of Our Credo as crucial public policy is discussed and developed", he said.
Plank said his company "engages in innovation and sports, not politics".
But Intel CEO Brian Krzanich was more specific when he resigned a short time later, writing that while he had urged leaders to condemn "white supremacists and their ilk", many in Washington "seem more concerned with attacking anyone who disagrees with them".
Facing Twitter attacks from the commander in chief, large companies often see their stock prices tumble.
Drug manufacturers have come under withering criticism for soaring prices in the U.S., including by Trump, though he has yet to act on a promise to contain them.
"Based on our conversations with investors, we believe most respect Mr. Frazier's decision", the analysts wrote.
"On Monday afternoon, following pressure from activists and politicians from both parties, he did specifically name the groups in a statement given at the White House".
I'm resigning from the Manufacturing Jobs Initiative because it's the right thing for me to do.
Several executives from top US companies have stepped down from a number of presidential advisory councils in protest to Trump policies.
Krzanich also was vocal in his statement of resignation, indicating that he "resigned to call attention to the serious harm our divided political climate is causing to critical issues, including the serious need to address the decline of American manufacturing".