The Chilean winger has missed the first two Prem games of the Gunners campaign due to an abdominal strain picked up in training.
The Frenchman is ready to use Sanchez this time out, following his return to fitness.
But Wenger, speaking at his press conference ahead of the weekend's action, said: "Sanchez has worked very hard to be back again and is available". Granted, this may be completely premature and I could well end up with egg on my face come next May, but it certainly looks as though there's no longer any point in talking about a top six at the top of the league.
"I don't think he is too much disturbed by all the noises".
Nothing has changed and at this stage, I find it hard to watch lads like Mesut Ozil, the player everyone raved about as a Player of the Year candidate half way through last season.
The Alexis Sanchez "will he leave, won't he leave" transfer saga has rumbled on for months now, with the rumours of an imminent exit failing to dissipate despite Arsene Wenger insisting the Chile worldwide will not be sold by Arsenal.
But Wenger conceded on Thursday that the France worldwide will not be making the move across the Channel as the Ligue 1 champions face losing some of their other title-winning stars. Monaco is at a stage where they've closed the door.
"They're still on cases like Kylian Mbappe and Fabinho".
However, the French champions, who have already lost Bernard Mendy, Tiemoue Bakayoko and Tiemoue Bakayoko, now appear set to keep hold of their highly-rated young star.
Alex Oxlade-Chamberlain is another player with less than a year of his deal to run and Wenger said he wanted the 24-year-old to stay at the club.
"We have our agendas, which are quite busy, but we do not publish them".
"My secretary has my agenda, I will check what I have to do today".
"The modern life has created maybe a bit less natural leadership because more players are better informed and have a bigger knowledge of the game so everybody contributes". He's one of the players the team can be built around, I want him to commit and be one of the carriers of the values of this team.