The incident also forced the facility to evacuate.
"To my knowledge and to my understanding, what I have right now, there's a total of five deaths from the same facility", Sharief said.
The chief of Hollywood police said a criminal investigation has been opened up into the deaths of the residents, but did not offer any further details.
Police said the building was sealed off and a criminal investigation is underway.
WSVN-TV report that the nursing home did appear to have a back up generator, although it does not appear to have been working.
Rescue crews began evacuating the Rehabilitation Center at Hollywood Hills early Wednesday to evacuate scores more from the the facility, NBC Miami reports.
Dave Long, a fix man, told WPLG that the building's air conditioning unit fell out during Hurricane Irma. Families looking for information can call the hospital hotline at 954-265-1074. "We've been calling and calling".
The temperature in Hollywood for Wednesday is expected to get up to 88 degrees with 74% humidity.
This developing news story will be updated.