The Owls could have two long term injury absentees back in the form of Sam Hutchinson and Almen Abdi who've both been out since early August with knee injuries.
The Blades captain missed last Saturday's defeat by Norwich and Ched Evans could keep his place if Sharp cannot play. The Blades will be able to call on midfielder Paul Coutts after no further action was taken against him by the Football Association following an off-the-ball incident in the game with Norwich.
It is the Owls, though, who have had the upper hand in the last decade, with Sheffield United winning just one of the last eight contests between these bitter city rivals.
There have been goals scored at both ends in eight of Wednesday's last nine matches in all competitions and Betsafe go 87/100 (1.87) that the trend continues in this clash, while the same firm go 113/100 (2.13) that there are more than two goals in the game - a selection that would have landed in both of Wednesday's last two matches at Hillsborough.
Wednesday have won three of their last four meetings with United on home soil, while they have not lost to their neighbours at Hillsborough since 2006.
Sheffield United striker Billy Sharp is a doubt with injury.
United are looking to win three consecutive Championship away games for the first time since December 2007.
The first Steel City derby in more than five years and what an occasion this is going to be! "All I have ever really wanted against Sheff Wednesday is three points".