Orbital OTK rescheduled the launch for 7:14 a.m. Sunday.
The launch should be visible as far north as Boston and as far south as Myrtle Beach, South Carolina, although the rising sun will make it tough to see.
The International Space Station is getting a delivery shipped from NASA's Wallops Flight Facility on Virginia's Eastern Shore.
There is a catch for anyone who heads outside to witness it: Saturday morning will be frigid, possibly coming off a record low temperature for the date.
The US space agency said the weather forecast for the new five-minute launch window was 90-per-cent favourable.
"We were working no issues until an aircraft flew into restricted airspace", the company said on Twitter. The supply run marks the second ISS mission for this type of spacecraft, The Washington Post reports.
The next launch effort is set for 7:14 a.m. Sunday.
"Scientists believe that the results of this experiment could help design effective countermeasures to protect astronauts' health during long-duration human space missions".
Hosting its first major mission in more than a year, Wallops attracted the customary crush of visitors.
Among the thousands of pounds of supplies are several science experiments, including an experiment designed to measure antibiotic resistance in microgravity. Live NASA TV coverage and commentary will begin at 7 a.m., and Wallops will play live views of the launch pad on Ustream beginning at 1:15 a.m. And it may go down as one of the last to bear the familiar Orbital logo.